New Direction
Unlocking an entirely new space within drug science based on our proprietary platform
ROLE OF PRM-BINDING PROTEIN DOMAINS
Only a minor fraction of the proteome is considered as druggable
Proline-rich motif (PRM) mediated interactions are the most frequent type of protein-protein interaction in our organism.
They are fundamental drivers of cellular malfunctions resulting in e.g. cancer cell migration, fibrosis as well as in bacterial and viral pathogenesis.
selected targets
YAP1
ENA/VASP
CD2BP2
FYN
The challenge to unlock this undruggable class of targets lies in the unique helical structure they are specialized in recognizing. Until now, all attempts to mimic this specific shape with small molecules have failed.
That is exactly where our technology comes into play.
Unlocking PRM-binding domains
THE SCIENCE BEHIND PROM'S
Meet ProM
Mimicking the complex 3D-structure of PRMs
ProMs are the first and currently only mimetics of the left-handed poly-L-proline type-II (PPII) Helix - the preferentially adopted conformation of proline-rich motifs (PRM) in protein domains.
selected targets
We combine our ProMs with our Development Platform to build a diversified pipeline of high value assets.
Step 1
Generating
Based on our modular synthetic approach we are able to fast-track the generation of ProM-based low molecular weight inhibitors for a target of choice
pipeline
developement progress
Ongoing
Halted
